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In contrast, no benefits on the rate of decline in glomerular filtration rate have been seen in trials of DPP-4 inhibitors, perhaps because the renal actions of DPP-4 inhibitors are primarily mediated by potentiation of SDF-1, not GLP-1

GLP-1 stimulation induced serine phosphorylation of wild-type GLP-1R, which was abolished in all individual doublet as well as triple doublet phospho-null mutants

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This condition carries a global mortality rate of approximately 8% and is characterized by significantly elevated creatine kinase (CK) levels, often rising to five times the normal upper limit or higher

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Alhazmi A & le Roux CW